MovDisordV3, Main, Exploration, bibRecord, 001131

Entorhinal Cortex Atrophy Differentiates Parkinson's Disease Patients With and Without Dementia

Identifieur interne : 001131 ( Main/Exploration ); précédent : 001130; suivant : 001132

Entorhinal Cortex Atrophy Differentiates Parkinson's Disease Patients With and Without Dementia

Auteurs : Jennifer G. Goldman [États-Unis] ; Glenn T. Stebbins [États-Unis] ; Bryan Bernard [États-Unis] ; Travis R. Stoub [États-Unis] ; Christopher G. Goetz [États-Unis] ; Leyla Detoledo-Morrell [États-Unis]

Source :

Movement disorders [ 0885-3185 ] ; 2012.

RBID : Pascal:12-0248753

Descripteurs français

Pascal (Inist)
- Atrophie, Maladie de Parkinson, Démence d'Alzheimer, Pathologie du système nerveux, Cortex entorhinal, Homme, Cognition, Imagerie RMN, Lobe temporal.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Alzheimer disease, Atrophy, Cognition, Dementia (complications), Dementia (pathology), Disease Progression, Entorhinal Cortex (pathology), Entorhinal cortex, Female, Hippocampus (pathology), Human, Humans, Magnetic Resonance Imaging, Male, Memory Disorders (complications), Memory Disorders (pathology), Middle Aged, Nervous system diseases, Neuropsychological Tests, Nuclear magnetic resonance imaging, Organ Size, Parkinson Disease (complications), Parkinson Disease (pathology), Parkinson disease, Temporal lobe.
MESH :
- complications : Dementia, Memory Disorders, Parkinson Disease.
- pathology : Dementia, Entorhinal Cortex, Hippocampus, Memory Disorders, Parkinson Disease.
- Aged, Aged, 80 and over, Atrophy, Disease Progression, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Organ Size.

Abstract

Volumetric measures of mesial temporal lobe structures on MRI scans recently have been explored as potential biomarkers of dementia in patients with PD, with investigations primarily focused on hippocampal volume. Both in vivo MRI and postmortem tissue studies in Alzheimer's disease, however, demonstrate that the entorhinal cortex (ERC) is involved earlier in disease-related pathology than the hippocampus. The ERC, a region integral in declarative memory function, projects multimodal sensory information to the hippocampus through the perforant path. In PD, ERC atrophy, as measured on MRI, however, has received less attention, compared to hippocampal atrophy. We compared ERC and hippocampal atrophy in 12 subjects with PD dementia including memory impairment, 14 PD subjects with normal cognition, and 14 healthy controls with normal cognition using manual segmentation methods on MRI scans. Though hippocampal volumes were similar in the two PD cognitive groups, ERC volumes were substantially smaller in the demented PD subjects, compared to cognitively normal PD subjects (P < 0.05). In addition, normalized ERC and hippocampal volumes for right and left hemispheres were significantly lower in the demented PD group, compared to healthy controls. Our findings suggest that ERC atrophy differentiates demented and cognitively normal PD subjects, in contrast to hippocampal atrophy. Thus, ERC atrophy on MRI may be a potential biomarker for dementia in PD, particularly in the setting of memory impairment.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366041

Affiliations:

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
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<term>Cognition</term>
<term>Dementia (complications)</term>
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<term>Entorhinal cortex</term>
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<term>Hippocampus (pathology)</term>
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<term>Parkinson disease</term>
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<front><div type="abstract" xml:lang="en">Volumetric measures of mesial temporal lobe structures on MRI scans recently have been explored as potential biomarkers of dementia in patients with PD, with investigations primarily focused on hippocampal volume. Both in vivo MRI and postmortem tissue studies in Alzheimer's disease, however, demonstrate that the entorhinal cortex (ERC) is involved earlier in disease-related pathology than the hippocampus. The ERC, a region integral in declarative memory function, projects multimodal sensory information to the hippocampus through the perforant path. In PD, ERC atrophy, as measured on MRI, however, has received less attention, compared to hippocampal atrophy. We compared ERC and hippocampal atrophy in 12 subjects with PD dementia including memory impairment, 14 PD subjects with normal cognition, and 14 healthy controls with normal cognition using manual segmentation methods on MRI scans. Though hippocampal volumes were similar in the two PD cognitive groups, ERC volumes were substantially smaller in the demented PD subjects, compared to cognitively normal PD subjects (P < 0.05). In addition, normalized ERC and hippocampal volumes for right and left hemispheres were significantly lower in the demented PD group, compared to healthy controls. Our findings suggest that ERC atrophy differentiates demented and cognitively normal PD subjects, in contrast to hippocampal atrophy. Thus, ERC atrophy on MRI may be a potential biomarker for dementia in PD, particularly in the setting of memory impairment.</div>
</front>
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<name sortKey="Stoub, Travis R" sort="Stoub, Travis R" uniqKey="Stoub T" first="Travis R." last="Stoub">Travis R. Stoub</name>
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Movement Disorders (revue)

Entorhinal Cortex Atrophy Differentiates Parkinson's Disease Patients With and Without Dementia

Entorhinal Cortex Atrophy Differentiates Parkinson's Disease Patients With and Without Dementia

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Movement Disorders (revue)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.